Map - O'Higgins Region (Región del Libertador General Bernardo O’Higgins)

The Libertador General Bernardo O'Higgins Region (Región del Libertador General Bernardo O'Higgins, ), often shortened to O'Higgins Region (Región de O'Higgins), is one of Chile's 16 first order administrative divisions. It is subdivided into three provinces. It is named in honour of Bernardo O'Higgins Riquelme, one of Chile's founding fathers.

The Libertador General Bernardo O'Higgins Region is bordered to the west by the Pacific Ocean, to the east by the Republic of Argentina, to the north by the Valparaíso and Santiago Metropolitan Regions, and to the south by the Maule Region. It extends approximately between the parallels of 33° 51' and 35° 01' south latitude, and between the meridian of 70° 02' west longitude and the Pacific Ocean.

The capital and largest city of the region is Rancagua. The second major town is San Fernando.

In pre-Quaternary times extensive Nothofagus forests covered much of Libertador General Bernardo O'Higgins Region.

The Libertador General Bernardo O'Higgins Region is part of the very restricted range of the endangered Chilean Wine Palm, Jubaea chilensis; in prehistoric times this Chilean endemic tree had a significantly larger range.